Program
Wednesday 17 March
| Welcome | Jean-Pierre Pouget - Institut de Recherche en Cancérologie de Montpellier, France |
| Chairs: Bart Cornelissen, Danny Feijtel | |
| 14:00 | Invited live lecture: MRT in neuroendocrine tumours: role of radiobiology(20+10 min) Emmanuel Deshayes, ICM Montpellier, France |
| Live talks: | |
| 14:30 | Target heterogeneity in models for peptide receptor radionuclide therapy influences therapeutic response (10min + 5min) Danny Feijtel, Erasmus MC, Netherland |
| 14:45 | Auger electrons for molecular radionuclide therapy: the potential of the radionuclide technetium-99m (10min + 5min) Inès Costa, King's College of London, United-Kingdom |
| 15:00 | High-throughput screening and bioinformatics analysis of 2,000177Lu-PSMA and Radiotherapy + drug combinations (10min + 5min) Tiffany Chan, University of Oxford, United-Kingdom |
| 15:15 | α-Particle-induced DNA damage tracks in peripheral blood mononuclear cells of [223Ra]RaCl2-treated prostate cancer patients (10min + 5min) Uta Eberlein, University of Wurzburg, Germany |
| 15:30 | Break (15min) |
| Chairs: Samantha Terry, Sophie Poty | |
| 15:45 | Invited live lecture on the therapy of micrometastasis and residual disease: Choice of the radionuclide and target in the therapy of metastatic and residual disease: needs in radiobiology (20+10 min) Elif Hindie, CHU Bordeaux, France |
| 16:15 | Presentation and discussion around the future work of the MRT Radiobiology working group (30min) Jean-Pierre Pouget, Bart Cornelissen, Julie Nonnekens, Samantha Terry and all attendees |
| 16:45 | Surprising presentation of Montpellier’s way of life! (5min) |
| 16:50 | Teaser for the Thursday’s “for and against” debate (1min) |
| 16:51 | Summary of the day Jean-Pierre Pouget, Bart Cornelissen |
Thursday 18 March
| Chairs: Manuel Bardiès, Marta Cremonesi | |
| 10:00 | Invited live lecture: Dose-effect relationship in clinical MRT: a place for radiobiology? (20+10 min) Mark W. Konijnenberg, Erasmus MC Rotterdam, Netherlands |
| Chair: Julie Nonnekens | |
| 10:30 | Entertaining and passionate debate followed by one final vote of participants (30min) This house believes that radiobiology is useful for improving MRT? For: Frederik Verburg (Nucl. Med. Physician, Erasmus MC Rotterdam Netherlands) Against: Christophe Badie (Radiobiologist, Public Health England Oxfordshire, United-Kingdom) |
| Chairs: Bart Cornelissen, Jean-Pierre Pouget | |
| 11:00 | Round tables: What are the immediate clinical questions in MRT? (45min) Participants: Emmanuel Deshayes (ICM, Montpellier, France), Elif Hindie (CHU Bordeaux, France), Katherine Vallis (University of Oxford, United-Kingdom), M. Gaze (University College London Hospitals NHS Foundation Trust, United-Kingdom) |
| 11:45 | Break (15min) |
| Chairs: Bart Cornelissen, Samantha Terry | |
| 12:00 | Round table about the future work of the MRT Radiobiology working group (45min) Participants: all Expert view: Kevin Prise Expert view: Simon Bouffler |
| 12:45 | Lunchbreak |
| 13:15 | Sponsors’ time
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| Chairs: Christophe Badie, Édouard Azzam | |
| 14:00 | Invited live lecture: Low dose and low dose rate radiobiology of MRT (20+10 min) Eva Forssell-Aronsson, University of Gothenburg, Sweden |
| 14:30 | E-posters: 8 preselected abstracts (5 min) +Q/A at the end for all (5 min) |
| Therapeutic investigation of Auger electron emitter 67Ga-DOTA-PSMA and 67Ga (5 min) Élise Verger, King’s College London, London, United-Kingdom |
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| Potentiation of targeted radionuclide therapy using gadolinium-based nanoparticles (5 min) Clara Diaz Garcia-Prada, Institut de Recherche en Cancérologie de Montpellier, France |
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| Extensive preclinical evaluation of Lutetium-177 labeled PSMA-specific tracers for prostate cancer radioligand therapy (5 min) Eline Ruigrok, Erasmus MC, Rotterdam, The Netherlands |
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| Multicellular prostate tumor spheroids for evaluation of the therapeutic potential of copper-64 (5 min) Catarino Pinto, Instituto Superior Técnico, Universidade de Lisboa |
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| DNA Damage response speed imaging predicts is survival following Lutetium-177 radionuclide therapy in vivo (5 min) Edward O'Neill, University of Oxford, Oxford, United-Kingdom |
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| Dosimetry at the cellular level: measuring reactive oxygen species induced by ionizing radiation (5 min) Eero Hippeläinen, University of Helsinki and Helsinki University Hospital, Finland |
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| Role of small extracellular vesicles in the non-targeted bystander effects of targeted radiotherapy (5 min) Jihad Karam, Institut de Recherche en Cancérologie de Montpellier, France |
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| Relating DNA damaging effects of radionuclides to those from external beam radiotherapy (5 min) Elise Verger, King’s College London, London, United-Kingdom |
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| 15:15 | Break (15min) |
| Chairs: Sandra Heskamp, Julie Constanzo | |
| Live talks: | |
| 15:30 | Molecular response of head and neck squamous cell carcinoma (HNSCC) upon a combination treatment with molecular- and external radiotherapy (10 min + 5 min) Treewut Rassamegevanon, National Center for Radiation Research in Oncology, Germany |
| 15:45 | P53-mediated radiosensitization of 177Lu-DOTATATE treatment in neuroblastoma tumor spheroids (10 min + 5 min) Sara Lundsten, Uppsala University, Sweden |
| 16:00 | Reversing cold tumor microenvironment with targeted alpha-therapy (10 min + 5 min) Justine Perrin, Centre de Recherche en Cancérologie et Immunologie Nantes Angers, France |
| 16:15 | Cytosolic dsDNA and extracellular vesicles participate to antitumor immunity induced by external and targeted radiotherapy (10 min + 5 min) Julie Constanzo, Institut de Recherche en Cancérologie de Montpellier, France |
| 16:30 | Invited live lecture Radiation oncology and immunology (20 + 10 min) Claire Vanpouille-Box, Weill Cornell Medicine, New-York, USA |
| 17:00 | Awards ceremony + summary |
| 17:30 | End of workshop by Jean-Pierre Pouget |
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